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- Title
Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry.
- Authors
Qihong Zhang; Jingbo Yu; Yingyao Wang; Weike Su
- Abstract
Flavonoids from Sophora flavescens were selectively extracted by mechanochemical-promoted extraction technology (MPET) after using response surface methodology to determine the optimal extraction parameters. The highest yield of 35.17 mg/g was achieved by grinding the roots with Na2CO3 (15%) at 440 rpm/min for 17.0 min and water was used as the sole solvent with a ratio of solvent to solid material of 25 mL/g. Flavonoids prepared by MPET demonstrated relatively higher antioxidant activities in subsequent DPPH and hydroxyl radical scavenging assays. Main constituents in the extracts, including kurarinol, kushenol I/N and kurarinone, were characterized by HPLC-MS/MS, indicating good selective extraction by MPET. Physicochemical property changes of powder during mechanochemical milling were identified by scanning electron microscopy, X-ray powder diffraction, and UV-Vis diffuse-reflectance spectroscopy. Compared with traditional extraction methods, MPET possesses notable advantages of higher selectivity, lower extraction temperature, shorter extraction time, and organic solvent free properties.
- Subjects
FLAVONOIDS; SOPHORA; MECHANICAL chemistry; EXTRACTION techniques; SCANNING electron microscopy
- Publication
Molecules, 2016, Vol 21, Issue 8, p989
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21080989