We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nucleophilic Trapping Nitrilimine Generated by Photolysis of Diaryltetrazole in Aqueous Phase.
- Authors
Yixin Zhang; Wujun Liu; Zongbao K. Zhao
- Abstract
Nitrilimine generated by photolysis of diaryltetrazole in aqueous phase under mild conditions was trapped by nucleophiles including amines and thioalcohols. The representative products were characterized, while products with all 20 natural amino acids and a peptide were observed by MALDI-TOF mass spectroscopy. Competitive studies showed that this reaction also occurred in the presence of acrylamide. These results provided new information for understanding the potential side reactions when tetrazole-alkene pairs were used as a bioorthogonal reaction in labeling proteins and related studies in buffered systems.
- Subjects
NITRILIMINES; ACRYLAMIDE; ACRYLATES; MASS spectrometry; IMINO acids
- Publication
Molecules, 2014, Vol 19, Issue 1, p306
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules19010306