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- Title
Antioxidant Capacity of Two Novel Bioactive Fe(III)-Cyclophane Complexes.
- Authors
Salazar-Medina, Alex J.; Sugich-Miranda, Rocío; Teran-Cabanillas, Eli; Hernández, Jesús; González-Aguilar, Gustavo A.; Rudiño-Piñera, Enrique; Sotelo-Mundo, Rogerio R.; Velázquez-Contreras, Enrique F.
- Abstract
The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models
- Subjects
CYCLOPHANES; MANGANESE enzymes; SUPEROXIDE dismutase; METALLOENZYMES; BIOMIMETIC chemicals
- Publication
Molecules, 2013, Vol 18, Issue 2, p1762
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18021762