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- Title
Squalene Emulsions for Parenteral Vaccine and Drug Delivery.
- Authors
Fox, Christopher B.
- Abstract
Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.
- Subjects
SQUALENE; IMMUNOLOGICAL adjuvants; SOLUBILITY; VACCINES; DRUGS; EMULSIONS (Pharmacy); DOSAGE forms of drugs; HYDROCARBONS; ORGANIC compounds; OCTYL alcohol
- Publication
Molecules, 2009, Vol 14, Issue 9, p3286
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14093286