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- Title
Genetic characterization of a novel HIV-1 CRF01_AE/CRF07_BC recombinant form among men who have sex with men in Guangdong, China.
- Authors
Lan, Yun; Zhu, Wenchang; Hu, Fengyu; Tang, Shixing; Li, Linghua; Cai, Xiaoli; Tang, Xiaoping; Cai, Weiping
- Abstract
Genome recombination is a major strategy employed by HIV to generate new variants for the benefit of escaping immune surveillance. Near full-length genome phylogenic analysis was utilized to characterize HIV diversity in a male patient in Guangdong, China. The result showed a unique recombinant form (URF) composed of two circulating recombinant forms, CRF01_AE (92%) and CRF07_BC (8%), using six recombinant breakpoints, nt 2794, 3092, 4482, 5988, 7021, and 7722. The emergence of this URF indicates that HIV-1 co-infection or super-infections are common. The increasing genetic complexity of the HIV-1 epidemic in China warrants continued investigation.
- Subjects
GUANGDONG Sheng (China); HIV infections; MEN who have sex with men; PHYLOGENY; GENETIC recombination; DISEASES
- Publication
Archives of Virology, 2018, Vol 163, Issue 11, p3093
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-018-3928-1