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- Title
TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence.
- Authors
Wang, Tzu-Yun; Lee, Sheng-Yu; Chung, Yi-Lun; Chen, Shiou-Lan; Li, Chia-Ling; Chang, Yun-Hsuan; Wang, Liang-Jen; Chen, Po See; Chen, Shih-Heng; Chu, Chun-Hsien; Huang, San-Yuan; Tzeng, Nian-Sheng; Hsieh, Tsai-Hsin; Lee, I. Hui; Chen, Kao Chin; Yang, Yen Kuang; Hong, Jau-Shyong; Lu, Ru-Band
- Abstract
<bold>Background: </bold>Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence.<bold>Methods: </bold>Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism.<bold>Results: </bold>The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (x03C7;2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients.<bold>Conclusions: </bold>Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.
- Subjects
DRUG addiction; ALCOHOLISM; SEROTONIN; DRUG abuse; ALCOHOL Dependence Scale; POLYMERASE chain reaction; RESTRICTION fragment length polymorphisms; GENETICS; DISEASE susceptibility; GENES; GENETIC polymorphisms; MEMBRANE proteins; OXIDOREDUCTASES; SUBSTANCE abuse; GENOTYPES
- Publication
European Addiction Research, 2016, Vol 22, Issue 4, p201
- ISSN
1022-6877
- Publication type
journal article
- DOI
10.1159/000444676