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- Title
Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat.
- Authors
Trofimova, E. S.; Zykova, M. V.; Danilets, M. G.; Ligacheva, A. A.; Sherstoboev, E. Yu.; Tsupko, A. V.; Mikhalyov, D. A.; Belousov, M. V.
- Abstract
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNFα, IL-1β, and IFNγ by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
- Subjects
HUMIC acid; IMMUNOCOMPETENT cells; ERYTHROCYTES; PERITONEAL macrophages; PEAT mosses; MITOGENS; PEAT
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 4, p461
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05088-5