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- Title
Efficiency of Noopept in Streptozotocin-Induced Diabetes in Rats.
- Authors
Ostrovskaya, R.; Ozerova, I.; Gudascheva, T.; Kapitsa, I.; Ivanova, E.; Voronina, T.; Seredenin, S.
- Abstract
We studied the effects of new nootropic and neuroprotective drug Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) in various dosage regimens on the dynamics of glycemia, body weight, and pain sensitivity in rats receiving diabetogenic toxin streptozotocin. In experimental diabetic rats, Noopept alleviated glycemia and weight loss and normalized enhanced pain sensitivity. The normalizing effect of Noopept was most pronounced when it was administered as a preventive agent prior to injection of the toxin. Both preventive and therapeutic administration of Noopept (delayed injections included) significantly weakened the examined metabolic effects of diabetogenic toxin. Possible mechanisms of the antidiabetic action of Noopept are analyzed.
- Subjects
DIABETES; STREPTOZOTOCIN; ANTIOXIDANTS; NEUROTROPHINS; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2013, Vol 154, Issue 3, p334
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-013-1944-4