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- Title
Assesment of Damage in Juvenile Idiopathic Arthritis: Single Center Experience.
- Authors
Asadova, Sevda; Kisaarslan, Ayşenur Paç; Çiçek, Sümeyra Özdemir; Şahin, Nihal; Taşkın, Sema Nur; Doğantan, Şeyda; Poyrazoğlu, Muammer H.
- Abstract
After biological treatment options, quality of life and articular functions in patients with Juvenile Idiopathic Arthritis (JIA) have been maintained close to normal. It is essential to evaluate the activation and the articular and extra-articular damage during the disease course. This study aimed to evaluate the damage status and factors affecting JIA patients who were followed up in our clinic. Two hundred four JIA patients who had been followed up for two years or more were included. The data of the patients were collected retrospectively. Demographic data, comorbid diseases, laboratory data (at baseline and during follow-up), disease activity during the follow-up period, and treatments were evaluated. Disease activities, quality of life, and Juvenile Arthritis Damage Index articular(JADI-A) and extra-articular (E) were evaluated at the final examination. Factors affecting JADI-A and E were assessed by univariate and multivariate logistic regression analysis. In this study, 127 (62.6%) of the patients were female. The median age was 13 (IQR: 11-16), and the age at diagnosis was 7 (IQR: 4-10) years. The median follow-up time was 5 (IQR: 4-8) years. Ninety-two (45.3%) patients had comorbid diseases. JADI-A scores were median:0(min-max: 0-24), JADI-E scores were median:0(min-max:0-4) in whole study population. In multivariate analysis, the mean annual attacks number [OR: 1,759 (CI: 1,300-2,379], p: <0,001), mean annual eritrocyte sedimantation rate (ESR) [OR: 1,072 (CI: 1,021-1,125), p: 0.005], duration of metotrexate usage [OR: 1.029 (CI: 1.013-1.046, p: 0.001] and biological drug usage [OR: 5.810 (CI: 1.296-26.054), p: 0.022) were effective on JADI-A scores. The CRP value at the first admission [OR: 1.007 (CI: 1,000-1,014), p: 0.037], the mean annual ESR value [OR: 1,051 (CI: 1,008-1,095), p: 0.019] were found to be effective on the JADI-E scores. The ideal cut-off point of the annual attacks number and mean annual ESR affecting JADI-A scores were 1.38 [AUC: 0.734 (0.641-0.828), p: 0.001] and 14.32 [AUC: 0.617 (0.514-0.721), p: 0.027], respectively. The ideal cut-off point of the CRP value at the first admission and mean annual ESR value affecting JADI-E scores were 13,25 [AUC: 0,662 (0,541-0,782), p: 0,009], and 15,10 [AUC: 0.674(0.567-0.780), p: 0.002], respectively. Steroid related complications such as, obesity in 12 (5.9%), hirsutism in 3 (1.5%), transient adrenal suppression in 14 (6.9%), 8 (3.9%), and osteoporosis determined in 7 (3.4%) patients. We have shown that parameters used routinely can be helpful to predict damage. We also think that new criteria should be added to the scoring.
- Subjects
ARTHRITIS; DISEASES; QUALITY of life; DEMOGRAPHIC surveys; MULTIVARIATE analysis
- Publication
Journal of Pediatric Academy (J. Pediatr. Acad.), 2022, Vol 3, Issue 3, p95
- ISSN
2718-0875
- Publication type
Article
- DOI
10.51271/jpea-2022-169