We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mediodorsal thalamus and ventral pallidum contribute to subcortical regulation of the default mode network.
- Authors
Zhao, Yilei; Kirschenhofer, Tobias; Harvey, Michael; Rainer, Gregor
- Abstract
Humans and other animals readily transition from externally to internally focused attention, and these transitions are accompanied by activation of the default mode network (DMN). The DMN was considered a cortical network, yet recent evidence suggests subcortical structures are also involved. We investigated the role of ventral pallidum (VP) and mediodorsal thalamus (MD) in DMN regulation in tree shrew, a close relative of primates. Electrophysiology and deep learning-based classification of behavioral states revealed gamma oscillations in VP and MD coordinated with gamma in anterior cingulate (AC) cortex during DMN states. Cross-frequency coupling between gamma and delta oscillations was higher during DMN than other behaviors, underscoring the engagement of MD, VP and AC. Our findings highlight the importance of VP and MD in DMN regulation, extend homologies in DMN regulation among mammals, and underline the importance of thalamus and basal forebrain to the regulation of DMN. A study using electrophysiology, behavioral methods and modelling demonstrates the importance of the ventral pallidum and mediodorsal thalamus in DMN regulation in tree shrews.
- Subjects
DEFAULT mode network; THALAMUS; GLOBUS pallidus; CINGULATE cortex; SHREWS
- Publication
Communications Biology, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-024-06531-9