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- Title
Sitting Time Reduction and Blood Pressure in Older Adults: A Randomized Clinical Trial.
- Authors
Rosenberg, Dori E.; Zhu, Weiwei; Greenwood-Hickman, Mikael Anne; Cook, Andrea J.; Florez Acevedo, Stefani; McClure, Jennifer B.; Arterburn, David E.; Cooper, Julie; Owen, Neville; Dunstan, David; Perry, Stephen R.; Yarborough, Laura; Mettert, Kayne D.; Green, Beverly B.
- Abstract
Key Points: Question: Is sitting time reduction an effective strategy for improving blood pressure? Findings: In this randomized clinical trial of 283 older adults, there were greater reductions in sitting time and systolic blood pressure during 6 months in the intervention arm compared with the control condition. Meaning: Reducing sitting time could be a practical strategy for promoting cardiometabolic health in older populations. This randomized clinical trial of older adults in Washington state assesses whether a sedentary behavior reduction intervention can reduce sitting time and improve blood pressure. Importance: Practical health promotion strategies for improving cardiometabolic health in older adults are needed. Objective: To examine the efficacy of a sedentary behavior reduction intervention for reducing sitting time and improving blood pressure in older adults. Design, Setting, and Participants: This parallel-group randomized clinical trial was conducted in adults aged 60 to 89 years with high sitting time and body mass index of 30 to 50 from January 1, 2019, to November 31, 2022, at a health care system in Washington State. Intervention: Participants were randomized 1:1 to the sitting reduction intervention or a healthy living attention control condition for 6 months. Intervention participants received 10 health coaching contacts, sitting reduction goals, and a standing desk and fitness tracker to prompt sitting breaks. The attention control group received 10 health coaching contacts to set general healthy living goals, excluding physical activity or sedentary behavior. Main Outcomes and Measures: The primary outcome, measured at baseline, 3 months, and 6 months, was sitting time assessed using accelerometers worn for 7 days at each time point. Coprimary outcomes were systolic and diastolic blood pressure measured at baseline and 6 months. Results: A total of 283 participants (140 intervention and 143 control) were randomized (baseline mean [SD] age, 68.8 [6.2] years; 186 [65.7%] female; mean [SD] body mass index, 34.9 [4.7]). At baseline, 147 (51.9%) had a hypertension diagnosis and 97 (69.3%) took at least 1 antihypertensive medication. Sitting time was reduced, favoring the intervention arm, with a difference in the mean change of −31.44 min/d at 3 months (95% CI, −48.69 to −14.19 min/d; P <.001) and −31.85 min/d at 6 months (95% CI, −52.91 to −10.79 min/d; P =.003). Systolic blood pressure change was lower by 3.48 mm Hg, favoring the intervention arm at 6 months (95% CI, −6.68 to −0.28 mm Hg; P =.03). There were 6 serious adverse events in each arm and none were study related. Conclusions and Relevance: In this study of a 6-month sitting reduction intervention, older adults in the intervention reduced sedentary time by more than 30 min/d and reduced systolic blood pressure. Sitting reduction could be a promising approach to improve health in older adults. Trial Registration: ClinicalTrials.gov Identifier: NCT03739762
- Subjects
WASHINGTON (State); BODY mass index; RESEARCH funding; SEDENTARY lifestyles; STATISTICAL sampling; PHYSICAL fitness mobile apps; ACCELEROMETRY; HYPERTENSION; SEX distribution; RANDOMIZED controlled trials; WEARABLE technology; GOAL (Psychology); ANTIHYPERTENSIVE agents; DESCRIPTIVE statistics; AGE distribution; TREATMENT effectiveness; WAIST circumference; SITTING position; DIASTOLIC blood pressure; BLOOD pressure; QUALITY assurance; SYSTOLIC blood pressure; CONFIDENCE intervals; DATA analysis software; TIME; REGRESSION analysis
- Publication
JAMA Network Open, 2024, Vol 7, Issue 3, pe243234
- ISSN
2574-3805
- Publication type
Article
- DOI
10.1001/jamanetworkopen.2024.3234