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- Title
Epstein-Barr virus and methotrexate-related CNS lymphoma in a patient with rheumatoid arthritis.
- Authors
Migita, Kiyoshi; Miyashita, Taiichiro; Mijin, Toma; Sakito, Sohko; Kurohama, Hirokazu; Ito, Masahiro; Toda, Keisuke; Tsustumi, Keisuke; Baba, Hiroshi; Izumi, Yasumori; Kawakami, Atsushi; Niino, Daisuke; Ohshima, Kouichi
- Abstract
Patients with rheumatoid arthritis (RA), especially those treated with methotrexate (MTX), might have an increased risk of lymphoproliferative disorders that are associated with Epstein-Barr virus (EBV). We describe a case of EBV-associated central nervous system (CNS) lymphoma (diffuse large B-cell lymphoma) in a patient with RA on a short course of MTX treatment. The neoplastic cells express the B-cell surface markers (CD20, Pax-5 and CD30), and EBV-encoded RNA was demonstrated by in situ hybridization. The patient's lymphoma did not recur for the 8-year follow-up period after the tumor resection and cessation of MTX. MTX may promote EBV-positive CNS lymphoma in RA patient due to its immunosuppressive properties as well as reactivating latent EBV infection.
- Subjects
EPSTEIN-Barr virus diseases; METHOTREXATE; CENTRAL nervous system cancer; LYMPHOMAS; RHEUMATOID arthritis treatment; LYMPHOPROLIFERATIVE disorders; TUMOR markers; DISEASE risk factors
- Publication
Modern Rheumatology, 2013, Vol 23, Issue 4, p832
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-012-0717-7