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- Title
Selective Cerebellar and Basal Ganglia Injury in Neuroleptic Malignant Syndrome.
- Authors
Lyons, Jennifer L.; Cohen, Adam B.
- Abstract
ABSTRACT BACKGROUND AND PURPOSE High core body temperatures have been shown to selectively damage the cerebellum and basal ganglia in malignant hyperthermia, but involvement of both areas in neuroleptic malignant syndrome (NMS) has not been described. METHODS Here, we report a case of acute cerebellar and basal ganglia injury by magnetic resonance imaging (MRI) in the setting of NMS. We discuss the pathophysiology, both of NMS and hyperthermic brain injury. RESULTS MRI showed new restricted diffusion in cerebellar hemispheres bilaterally and right basal ganglia when compared with brain MRI obtained 1 month prior. T2 FLAIR hyperintensities corresponding to diffusion restriction were also seen in the cerebellum. CONCLUSIONS Both the basal ganglia and cerebellum can be injured selectively in NMS.
- Subjects
CEREBELLAR ataxia; BASAL ganglia; NEUROLEPTIC malignant syndrome; MALIGNANT hyperthermia; PATHOLOGICAL physiology; CEREBELLUM; MAGNETIC resonance imaging
- Publication
Journal of Neuroimaging, 2013, Vol 23, Issue 2, p240
- ISSN
1051-2284
- Publication type
Article
- DOI
10.1111/j.1552-6569.2011.00579.x