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- Title
Time-resolved RNA signatures of CD4+ T cells in Parkinson's disease.
- Authors
Diener, Caroline; Hart, Martin; Kehl, Tim; Becker-Dorison, Anouck; Tänzer, Tanja; Schub, David; Krammes, Lena; Sester, Martina; Keller, Andreas; Unger, Marcus; Walch-Rückheim, Barbara; Lenhof, Hans-Peter; Meese, Eckart
- Abstract
Parkinson's disease (PD) emerges as a complex, multifactorial disease. While there is increasing evidence that dysregulated T cells play a central role in PD pathogenesis, elucidation of the pathomechanical changes in related signaling is still in its beginnings. We employed time-resolved RNA expression upon the activation of peripheral CD4+ T cells to track and functionally relate changes on cellular signaling in representative cases of patients at different stages of PD. While only few miRNAs showed time-course related expression changes in PD, we identified groups of genes with significantly altered expression for each different time window. Towards a further understanding of the functional consequences, we highlighted pathways with decreased or increased activity in PD, including the most prominent altered IL-17 pathway. Flow cytometric analyses showed not only an increased prevalence of Th17 cells but also a specific subtype of IL-17 producing γδ-T cells, indicating a previously unknown role in PD pathogenesis.
- Subjects
PARKINSON'S disease; GENE expression; T helper cells; CD4 antigen; T cells; CELL communication
- Publication
Cell Death Discovery, 2023, Vol 9, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-023-01333-0