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- Title
Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia.
- Authors
Ritsner, Michael; Gibel, Anatoly; Maayan, Rachel; Ratner, Yael; Ram, Edward; Biadsy, Hassan; Modai, Ilan; Weizman, Abraham
- Abstract
Dehydroepiandrosterone (DHEA) or their sulfate conjugate (DHEAS) (together abbreviated DHEA(S)) exert multiple effects in the central nervous system, and may be involved in the pathophysiological processes in schizophrenia. This prospective study aimed to investigate whether serum cortisol/DHEA(S) molar ratios are associated with response to antipsychotic treatment during the exacerbation of schizophrenia. Serum DHEA(S) and cortisol were determined at baseline, and 2 and 4 weeks later for 43 medicated schizophrenia inpatients with acute exacerbation. The patients were treated with stable doses of antipsychotic agents up to 2 weeks prior to entering the study and for the 4-week duration of the study after which they were classified as either responders or nonresponders to treatment. Findings suggest that responders had significantly higher serum cortisol levels and cortisol/DHEA(S) ratios compared with nonresponders. These differences remained significant at three time points controlling for gender, age, severity of symptoms and emotional distress, benzodiazepines, type or dosage of antipsychotic agents, and background variables. The logistic regression model shows advantages of both cortisol/DHEA(S) molar ratios vs serum cortisol and DHEA(S) concentrations for prediction of responsivity to antipsychotic treatment. No significant canonical correlations were observed between changes from baseline through end-of-study in hormonal values and severity of symptoms and emotional distress among responders and nonresponders. Thus, these data provide evidence that elevated serum cortisol and cortisol/DHEA(S) ratios may serve as markers of biological mechanisms that are involved in responsivity of schizophrenia patients to antipsychotic treatment.Neuropsychopharmacology (2005) 30, 1913–1922. doi:10.1038/sj.npp.1300747; published online 4 May 2005
- Subjects
DEHYDROEPIANDROSTERONE; CENTRAL nervous system; SCHIZOPHRENIA; HYDROCORTISONE; SERUM; ANTIPSYCHOTIC agents
- Publication
Neuropsychopharmacology, 2005, Vol 30, Issue 10, p1913
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300747