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- Title
Intranasal Treatment of Ferrets with Inert Bacterial Spores Reduces Disease Caused by a Challenging H7N9 Avian Influenza Virus.
- Authors
James, Joe; Meyer, Stephanie M.; Hong, Huynh A.; Dang, Chau; Linh, Ho T. Y.; Ferreira, William; Katsande, Paidamoyo M.; Vo, Linh; Hynes, Daniel; Love, William; Banyard, Ashley C.; Cutting, Simon M.
- Abstract
Background: Influenza is a respiratory infection that continues to present a major threat to human health, with ~500,000 deaths/year. Continued circulation of epidemic subtypes in humans and animals potentially increases the risk of future pandemics. Vaccination has failed to halt the evolution of this virus and next-generation prophylactic approaches are under development. Naked, "heat inactivated", or inert bacterial spores have been shown to protect against influenza in murine models. Methods: Ferrets were administered intranasal doses of inert bacterial spores (DSM 32444K) every 7 days for 4 weeks. Seven days after the last dose, the animals were challenged with avian H7N9 influenza A virus. Clinical signs of infection and viral shedding were monitored. Results: Clinical symptoms of infection were significantly reduced in animals dosed with DSM 32444K. The temporal kinetics of viral shedding was reduced but not prevented. Conclusion: Taken together, nasal dosing using heat-stable spores could provide a useful approach for influenza prophylaxis in both humans and animals.
- Subjects
INFLUENZA; INFLUENZA A virus, H7N9 subtype; BACTERIAL spores; FERRET; AVIAN influenza A virus; VIRAL shedding
- Publication
Vaccines, 2022, Vol 10, Issue 9, p1559
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10091559