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- Title
An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge.
- Authors
Rider, Paul J. F.; Kamil, Mohd; Yilmaz, Ilknur; Atmaca, Habibe N.; Kalkan-Yazici, Merve; Ziya Doymaz, Mehmet; Kousoulas, Konstantin G.; Aly, Ahmed S. I.
- Abstract
Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of mice with a pooled vaccine, composed of the three attenuated virus strains expressing each LS antigen, induced sterile protection against the intravenous challenge of Plasmodium yoelii 17X-NL salivary gland sporozoites. Our data suggest that this malaria vaccine may be effective in preventing malaria parasite infection using practical routes of immunization in humans.
- Subjects
MALARIA vaccines; HUMAN herpesvirus 1; PLASMODIUM yoelii; VIRAL proteins; VACCINE effectiveness
- Publication
Vaccines, 2022, Vol 10, Issue 2, p300
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10020300