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- Title
Comparative Analysis of the Productivity and Immunogenicity of an Attenuated Classical Swine Fever Vaccine (LOM) and an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BE rns) from Laboratory to Pig Farm.
- Authors
Choe, SeEun; Kim, Ki-Sun; Shin, Jihye; Song, Sok; Park, Gyu-Nam; Cha, Ra Mi; Choi, Sung-Hyun; Jung, Byung-Il; Lee, Kyung-Won; Hyun, Bang-Hun; Park, Bong-Kyun; An, Dong-Jun; Perez, Lester J.
- Abstract
Herein, we compared the productivity of pigs inoculated with one of two classical swine fever (CSF) vaccines (low virulent of Miyagi (LOM) or Flc-LOM-BErns) plus the swine erysipelothrix rhusiopathiae (SE) vaccine. The feed intake and weight increase of the pigs inoculated with Flc-LOM-BErns + SE were normal. However, the feed intake of the pigs inoculated with LOM + SE dropped sharply from four days post-vaccination (dpv). In addition, the slaughter date was an average of eight days later than that of the pigs inoculated with Flc-LOM-BErns + SE. All pigs inoculated with the Flc-LOM-BErns + SE vaccine were completely differentiated at 14 days against CSF Erns antibody and at approximately 45 days against the bovine viral diarrhea virus (BVDV) Erns antibody; the titers were maintained until slaughter. Leucopenia occurred temporarily in the LOM + SE group, but not in the Flc-LOM-BErns + SE group. Expression of tumor necrosis factor (TNF)-α and IFN-γ was significantly (p < 0.05) higher in the LOM + SE group than in the mock (no vaccine) group. When conducting the same experiment on a breeding farm, the results were similar to those of the laboratory experiments. In conclusion, the biggest advantage of replacing the CSF LOM vaccine with the Flc-LOM-BErns vaccine is improved productivity.
- Subjects
CLASSICAL swine fever; BOVINE viral diarrhea virus; SWINE farms; TUMOR necrosis factors; NURSES
- Publication
Vaccines, 2021, Vol 9, Issue 4, p381
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9040381