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- Title
Kutanöz Mozaisizm ve Mozaik Patern Gösteren Dermatozlar.
- Authors
ÖRENAY, Özge Mine; TAMER, Funda; SARIFAKIOĞLU, Evren
- Abstract
A mosaic organism is composed of two or more genetically different cell populations which are derived from a homogenous zygote. Mosaicism can be easily observed in the skin, clinically. In the skin, mosaicism emerges in certain patterns and helps to make diagnosis of mosaic diseases. The pattern of cutaneous mosaicism depends on the type of the affected cell and their trajectory of migration during embryogenesis. The most common of these patterns was first described by Alfred Blaschko in 1901 and named as Blaschko lines. Mosaic patterns except Blaschko lines have also been described. Classic patterns of cutaneous mosaicism are classified in five groups. They are defined as Type 1 Blaschko lines, Type 2 blocklike pattern, Type 3 phylloid pattern, Type 4 patchy pattern without midline separation and Type 5 lateralization pattern. Mosaic phenotypes can be examined under two major group according to the underlying genetic mechanism as genomic and functional mosaicism. Genomic mosaicism emerges when a cell undergoes a de novo postzygotic mutation. It usually occurs by autosomal mutations. Apart from the exceptions genetic heritance is not seen. Functional mosaicism occurs from the changes in gene expression. Can be caused from X inactivation. In particular, inherited from mother to her daughter. In this article, we aimed to explain cutaneous mosaicism patterns, pathogenesis and some of the common mosaic dermatoses. In addition, when skin findings observed in the mosaic pattern, especially association with neurological, musculoskeletal and ophthalmologic abnormalities should be kept in mind.
- Publication
Turkiye Klinikleri Journal of Dermatology, 2016, Vol 26, Issue 3, p140
- ISSN
1300-0330
- Publication type
Article
- DOI
10.5336/dermato.2016-51296