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- Title
Epigenetic Mechanisms of Depression.
- Authors
Nestler, Eric J.
- Abstract
The article discusses the influences of epigenetic mechanisms on depression. Topics discussed include mechanism of epigenetic regulation, changes in gene expression that are mediated via altered chromatin structure without modification of DNA sequence, epigenetic control of stress responses and the impact of histone acetylation, catalyzed by histone acetyltransferases and reversed by histone deacetylases (HDACs), on the increased gene expression.
- Subjects
EPIGENETICS; GENE expression; NUCLEOTIDE sequence; MENTAL depression genetics; HISTONE acetylation; ACETYLTRANSFERASES
- Publication
JAMA Psychiatry, 2014, Vol 71, Issue 4, p454
- ISSN
2168-622X
- Publication type
Article
- DOI
10.1001/jamapsychiatry.2013.4291