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- Title
Association study between vitiligo and autoimmune‐related genes CYP27B1, REL, TNFAIP3, IL2 and IL21.
- Authors
Martins, Laysa Toschi; Frigeri, Henrique Ravanhol; Castro, Caio Cesar Silva; Mira, Marcelo Távora
- Abstract
The aetiology of vitiligo has not been fully elucidated, and several hypotheses have been investigated; among them, the most explored assumes an autoimmune basis for the disease. Supporting this hypothesis is the frequent co‐occurrence of autoimmune diseases with vitiligo. In addition, various genetic loci associated with vitiligo harbour key immune response genes. Our general hypothesis is that autoimmunity‐associated genes participate in the control of vitiligo susceptibility. To investigate this hypothesis, we tested for association between vitiligo and genes CYP27B1, REL, TNFAIP3 and IL2/IL21, all previously related to autoimmune diseases associated with vitiligo. The study was performed using two independent population samples: a family‐based discovery set (211 trios) and a replication set (131 cases/119 controls). Statistically significant association with vitiligo was detected between markers of the REL and IL2 gene in the family‐based sample. Both association signals were concentrated among patients displaying autoimmune comorbidity and non‐segmental vitiligo. Evidence for validation was detected for IL2 marker. Our findings suggest REL and IL2 as new vitiligo susceptibility genes and reinforce the hypothesis of a shared genetic mechanism controlling vitiligo and other autoimmune diseases.
- Subjects
AUTOIMMUNE diseases; VITILIGO; GENES; IMMUNE response; ETIOLOGY of diseases
- Publication
Experimental Dermatology, 2020, Vol 29, Issue 6, p535
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.14100