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- Title
Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
- Authors
Du, Gang; Kataoka, Ken; Sakaguchi, Masakiyo; Abarzua, Fernando; Than, Swe Swe; Sonegawa, Hiroyuki; Makino, Teruhiko; Shimizu, Tadamichi; Huh, Nam-Ho
- Abstract
Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
- Subjects
EPIDERMIS; GROWTH factors; CELL differentiation; TUMOR suppressor genes; LABORATORY mice; CELL lines
- Publication
Experimental Dermatology, 2011, Vol 20, Issue 3, p273
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.1600-0625.2010.01244.x