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Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
Published in:
BMC Complementary Medicine & Therapies, 2020, v. 20, n. 1, p. 1, doi. 10.1186/s12906-020-2849-1
By:
- Ardah, Mustafa T.;
- Ghanem, Simona S.;
- Abdulla, Sara A.;
- Lv, Guohua;
- Emara, Mohamed M.;
- Paleologou, Katerina E.;
- Vaikath, Nishant N.;
- Lu, Jia-Hong;
- Li, Min;
- Vekrellis, Konstantinos;
- Eliezer, David;
- El-Agnaf, Omar M. A.
Publication type:
Article
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates.
Published in:
2020
By:
- Arotcarena, Marie-Laure;
- Dovero, Sandra;
- Prigent, Alice;
- Bourdenx, Mathieu;
- Camus, Sandrine;
- Porras, Gregory;
- Thiolat, Marie-Laure;
- Tasselli, Maddalena;
- Aubert, Philippe;
- Kruse, Niels;
- Mollenhauer, Brit;
- Damas, Ines Trigo;
- Estrada, Cristina;
- Garcia-Carrillo, Nuria;
- Vaikath, Nishant N;
- El-Agnaf, Omar M A;
- Herrero, Maria Trinidad;
- Vila, Miquel;
- Obeso, Jose A;
- Derkinderen, Pascal
Publication type:
journal article
ALPHA-SYNUCLEIN SPECIES AS POTENTIAL CSF BIOMARKERS FOR DEMENTIA WITH LEWY BODIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P338, doi. 10.1016/j.jalz.2017.06.063
By:
- van Steenoven, Inger;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Berendse, Henk W.;
- van der Flier, Wiesje M.;
- Van de Berg, Wilma D.J.;
- Teunissen, Charlotte E.;
- El-Agnaf, Omar M.A.;
- Lemstra, Afina W.
Publication type:
Article
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease.
Published in:
Scientific Reports, 2017, p. 40263, doi. 10.1038/srep40263
By:
- Majbour, Nour K.;
- Chiasserini, Davide;
- Vaikath, Nishant N.;
- Eusebi, Paolo;
- Tokuda, Takahiko;
- van de Berg, Wilma;
- Parnetti, Lucilla;
- Calabresi, Paolo;
- El-Agnaf, Omar M. A.
Publication type:
Article
RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 6, p. 820, doi. 10.3390/biom11060820
By:
- Poggiolini, Ilaria;
- Erskine, Daniel;
- Vaikath, Nishant N.;
- Ponraj, Janarthanan;
- Mansour, Said;
- Morris, Christopher M.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system.
Published in:
Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1203723
By:
- Schmidt, Frank;
- Abdesselem, Houari B.;
- Suhre, Karsten;
- Vaikath, Nishant N.;
- Sohail, Muhammad U.;
- Al-Nesf, Maryam;
- Bensmail, Ilham;
- Mashod, Fathima;
- Sarwath, Hina;
- Bernhardt, Joerg;
- Schaefer-Ramadan, Stephanie;
- Ti-Myen Tan;
- Morris, Priscilla E.;
- Schenck, Edward J.;
- Price, David;
- Mohamed-Ali, Vidya;
- Al-Maadheed, Mohammed;
- Arredouani, Abdelilah;
- Decock, Julie;
- Blackburn, Jonathan M.
Publication type:
Article
Expression, purification and characterization of α-synuclein fibrillar specific scFv from inclusion bodies.
Published in:
PLoS ONE, 2020, v. 15, n. 11, p. 1, doi. 10.1371/journal.pone.0241773
By:
- Gupta, Vijay;
- Sudhakaran, Indulekha P.;
- Islam, Zeyaul;
- Vaikath, Nishant N.;
- Hmila, Issam;
- Lukacsovich, Tamas;
- Kolatkar, Prasanna R.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit in‐vitro seeded aggregation and toxicity.
Published in:
FEBS Journal, 2022, v. 289, n. 15, p. 4657, doi. 10.1111/febs.16376
By:
- Hmila, Issam;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- Erskine, Daniel;
- Sudhakaran, Indulekha P.;
- Gupta, Vijay;
- Ghanem, Simona S.;
- Islam, Zeyaul;
- Emara, Mohamed M.;
- Abdesselem, Houari B.;
- Kolatkar, Prasanna R.;
- Achappa, Devaya K.;
- Vinardell, Tatiana;
- El‐Agnaf, Omar M. A.
Publication type:
Article
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65035-8
By:
- Gupta, Vijay;
- Salim, Safa;
- Hmila, Issam;
- Vaikath, Nishant N.;
- Sudhakaran, Indulekha P.;
- Ghanem, Simona S.;
- Majbour, Nour K.;
- Abdulla, Sara A.;
- Emara, Mohamed M.;
- Abdesselem, Houari B.;
- Lukacsovich, Tamas;
- Erskine, Daniel;
- El-Agnaf, Omar M. A.
Publication type:
Article
Heterogeneity in α‐synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.
Published in:
Neuropathology & Applied Neurobiology, 2019, v. 45, n. 6, p. 597, doi. 10.1111/nan.12531
By:
- Vaikath, N. N.;
- Erskine, D.;
- Morris, C. M.;
- Majbour, N. K.;
- Vekrellis, K.;
- Li, J.‐Y.;
- El‐Agnaf, O. M. A.
Publication type:
Article
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort.
Published in:
Viruses (1999-4915), 2021, v. 13, n. 5, p. 786, doi. 10.3390/v13050786
By:
- Smith, Muneerah;
- Abdesselem, Houari B.;
- Mullins, Michelle;
- Tan, Ti-Myen;
- Nel, Andrew J. M.;
- Al-Nesf, Maryam A. Y.;
- Bensmail, Ilham;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Naik, Adviti;
- Ouararhni, Khalid;
- Mohamed-Ali, Vidya;
- Al-Maadheed, Mohammed;
- Schell, Darien T.;
- Baros-Steyl, Seanantha S.;
- Anuar, Nur D.;
- Ismail, Nur H.;
- Morris, Priscilla E.;
- Mamat, Raja N. R.;
- Rosli, Nurul S. M.
Publication type:
Article
Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases.
Published in:
Brain Pathology, 2020, v. 30, n. 4, p. 831, doi. 10.1111/bpa.12845
By:
- Fayyad, Muneera;
- Erskine, Daniel;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Ghanem, Simona S.;
- Sudhakaran, Indulekha P.;
- Abdesselem, Houari;
- Lamprokostopoulou, Agaristi;
- Vekrellis, Kostas;
- Morris, Christopher M.;
- Attems, Johannes;
- El‐Agnaf, Omar M. A.
Publication type:
Article
Antibodies against alpha‐synuclein: tools and therapies.
Published in:
Journal of Neurochemistry, 2019, v. 150, n. 5, p. 612, doi. 10.1111/jnc.14713
By:
- Vaikath, Nishant N.;
- Hmila, Issam;
- Gupta, Vijay;
- Erskine, Daniel;
- Ingelsson, Martin;
- El‐Agnaf, Omar M. A.
Publication type:
Article
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
Published in:
2018
By:
- Duffy, Megan F.;
- Collier, Timothy J.;
- Patterson, Joseph R.;
- Kemp, Christopher J.;
- Luk, Kelvin C.;
- Tansey, Malú G.;
- Paumier, Katrina L.;
- Kanaan, Nicholas M.;
- Fischer, D. Luke;
- Polinski, Nicole K.;
- Barth, Olivia L.;
- Howe, Jacob W.;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- El-Agnaf, Omar M. A.;
- Sortwell, Caryl E.
Publication type:
corrected article
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
Published in:
2018
By:
- Patterson, Joseph R.;
- Kemp, Christopher J.;
- Barth, Olivia L.;
- Howe, Jacob W.;
- Duffy, Megan F.;
- Polinski, Nicole K.;
- Fischer, Luke D.;
- Collier, Timothy J.;
- Paumier, Katrina L.;
- Kanaan, Nicholas M.;
- Sortwell, Caryl E.;
- Luk, Kelvin C.;
- Tansey, Malú G.;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- El-Agnaf, Omar M. A.;
- Fischer, D Luke
Publication type:
journal article
Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum.
Published in:
Neurogastroenterology & Motility, 2017, v. 29, n. 4, p. n/a, doi. 10.1111/nmo.12985
By:
- Sharrad, D. F.;
- Chen, B. N.;
- Gai, W. P.;
- Vaikath, N.;
- El‐Agnaf, O. M.;
- Brookes, S. J. H.
Publication type:
Article
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0072-9
By:
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- van Dijk, Karin D.;
- Ardah, Mustafa T.;
- Varghese, Shiji;
- Vesterager, Louise B.;
- Montezinho, Liliana P.;
- Poole, Stephen;
- Safieh-Garabedian, Bared;
- Takahiko Tokuda;
- Teunissen, Charlotte E.;
- Berendse, Henk W.;
- van de Berg, Wilma D. J.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity.
Published in:
Molecules, 2021, v. 26, n. 12, p. 3736, doi. 10.3390/molecules26123736
By:
- Ghanem, Simona S.;
- Fayed, Hend S.;
- Zhu, Qi;
- Lu, Jia-Hong;
- Vaikath, Nishant N.;
- Ponraj, Janarthanan;
- Mansour, Said;
- El-Agnaf, Omar M. A.
Publication type:
Article
Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32588-8
By:
- Donadio, V.;
- Incensi, A.;
- El-Agnaf, O.;
- Rizzo, G.;
- Vaikath, N.;
- Del Sorbo, F.;
- Scaglione, C.;
- Capellari, S.;
- Elia, A.;
- Stanzani Maserati, M.;
- Pantieri, R.;
- Liguori, R.
Publication type:
Article
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.
Published in:
Translational Neurodegeneration, 2020, v. 9, n. 1, p. 1, doi. 10.1186/s40035-020-00192-4
By:
- Majbour, Nour K.;
- Aasly, Jan O.;
- Hustad, Eldbjørg;
- Thomas, Mercy A.;
- Vaikath, Nishant N.;
- Elkum, Naser;
- van de Berg, Wilma D. J.;
- Tokuda, Takahiko;
- Mollenhauer, Brit;
- Berendse, Henk W.;
- El-Agnaf, Omar M. A.
Publication type:
Article
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy.
Published in:
Translational Neurodegeneration, 2019, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40035-019-0159-7
By:
- Wu, Jia-Zhen;
- Ardah, Mustafa;
- Haikal, Caroline;
- Svanbergsson, Alexander;
- Diepenbroek, Meike;
- Vaikath, Nishant N.;
- Li, Wen;
- Wang, Zhan-You;
- Outeiro, Tiago F.;
- El-Agnaf, Omar M.;
- Li, Jia-Yi
Publication type:
Article
Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer's Disease.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 14, p. 11326, doi. 10.3390/ijms241411326
By:
- Sharari, Sanaa;
- Vaikath, Nishant N.;
- Tsakou, Magdalini;
- Ghanem, Simona S.;
- Vekrellis, Kostas
Publication type:
Article
α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.
Published in:
2018
By:
- Steenoven, Inger;
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Berendse, Henk W.;
- Flier, Wiesje M.;
- Berg, Wilma D.J.;
- Teunissen, Charlotte E.;
- Lemstra, Afina W.;
- El‐Agnaf, Omar M.A.;
- van Steenoven, Inger;
- van der Flier, Wiesje M;
- van de Berg, Wilma D J;
- El-Agnaf, Omar M A
Publication type:
journal article
Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression.
Published in:
2016
By:
- Majbour, Nour K.;
- Vaikath, Nishant N.;
- Eusebi, Paolo;
- Chiasserini, Davide;
- Ardah, Mustafa;
- Varghese, Shiji;
- Haque, M. Emdadul;
- Tokuda, Takahiko;
- Auinger, Peggy;
- Calabresi, Paolo;
- Parnetti, Lucilla;
- El‐Agnaf, Omar M.A.
Publication type:
journal article
Structural insights into the unique recognition module between α‐synuclein peptide and nanobody.
Published in:
Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 2, p. 1, doi. 10.1002/pro.4875
By:
- Islam, Zeyaul;
- Vaikath, Nishant N.;
- Hmila, Issam;
- El‐Agnaf, Omar M. A.;
- Kolatkar, Prasanna R.
Publication type:
Article

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