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- Title
The blue light receptor CRY1 interacts with FIP37 to promote N<sup>6</sup>‐methyladenosine RNA modification and photomorphogenesis in Arabidopsis.
- Authors
Yang, Jiaxin; Li, Lan; Li, Xin; Zhong, Ming; Li, Xinmei; Qu, Lina; Zhang, Hui; Tang, Dongying; Liu, Xuanming; He, Chongsheng; Zhao, Xiaoying
- Abstract
Summary: Light is a particularly important environmental cue that regulates a variety of diverse plant developmental processes, such as photomorphogenesis. Blue light promotes photomorphogenesis mainly through the activation of the photoreceptor cryptochrome 1 (CRY1). However, the mechanism underlying the CRY1‐mediated regulation of growth is not fully understood.Here, we found that blue light induced N6‐methyladenosine (m6A) RNA modification during photomorphogenesis partially via CRY1. Cryptochrome 1 mediates blue light‐induced expression of FKBP12‐interacting protein 37 (FIP37), which is a component of m6A writer. Moreover, we showed that CRY1 physically interacted with FIP37 in vitro and in vivo, and mediated blue light activation of FIP37 binding to RNA. Furthermore, CRY1 and FIP37 modulated m6A on photomorphogenesis‐related genes PIF3, PIF4, and PIF5, thereby accelerating the decay of their transcripts.Genetically, FIP37 repressed hypocotyl elongation under blue light, and fip37 mutation could partially rescue the short‐hypocotyl phenotype of CRY1‐overexpressing plants.Together, our results provide a new insight into CRY1 signal in modulating m6A methylation and stability of PIFs, and establish an essential molecular link between m6A modification and determination of photomorphogenesis in plants.
- Subjects
RNA modification &; restriction; BLUE light; PLANT photomorphogenesis; CRYPTOCHROMES; ARABIDOPSIS
- Publication
New Phytologist, 2023, Vol 237, Issue 3, p840
- ISSN
0028-646X
- Publication type
Article
- DOI
10.1111/nph.18583