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- Title
Dose -- response testing with nickel sulphate using the TRUE test® in nickel -- sensitive individuals. Multiple nickel sulphate patch -- test reactions do not cause an 'angry back'
- Authors
Andersen, K. E.; Liden, C.; Hansen, J.; Volund, A.
- Abstract
The aim of this study was to employ the TRUE test® assay to confirm the presence or absence of the ‘angry back’ phenomenon, i.e. that a strong positive patch-test reaction heightens adjacent patch-test response. In addition, we wished to establish the dose-response relationship for nickel sulphate patch tests among nickel-sensitive patients. Seventy-two nickel-sensitive patients, 36 in Odense and 56 in Stockholm, were tested with a 10-step nickel sulphate dilution series (TRUE test®) and two placebo patches. The position of the patches was rotated, to provide a balanced spatial distribution of the different concentrations. Readings were performed blind. The results were analysed by means of polynomial multiple-regression methods and a logistic dose-response model. Half the patients (38/72) had a threshold patch-test concentration for nickel sulphate in the range of 3–0.3 μ/cm2. The ‘angry back’ phenomenon was not apparent in this study, as the spill-over effect was not statistically significant. Strong reactions to high concentrations of nickel sulphate did not enhance the response to adjacent lower concentrations of nickel sulphate.
- Subjects
SKIN diseases; NICKEL sulfide; SULFIDES; DOSE-response relationship in biochemistry; DERMATOLOGY
- Publication
British Journal of Dermatology, 1993, Vol 129, Issue 1, p50
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1993.tb03311.x