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- Title
Systemic administration of etretin increases epidermal interleukin I in the rat.
- Authors
Schmitt, Andrea; Hauser, C.; Didierjean, Liliane; Merot, Y.; Dayer, J.-M.; Saurat, J.-H.
- Abstract
We have studied the effect of systemic administration of etretin (Ro 10–1670) on the epidermal interleukin 1 (IL1) pool in the rat. Hairless rats were given varying doses of etretin intraperitoneally for 21 days, or a fixed dose for 2, 8 and 16 days. Abdominal skin was taken and processed for light microscopy, autoradiography (using [³H]-thymidine) and IL1 assays. IL1 was assayed in supernatants of epidermal extracts by both the lymphocyte activating factor (LAF) assay and the stimulation of prostaglandin E2 (PGE2) release from dermal fibroblasts. A significant increase in both LAF and PGE2 stimulatory activities was found during etretin administration. After 21 days' treatment with varying doses there was a two- to three-fold increase as compared to the controls, with a peak at 2 and 5 mg/kg. At a fixed dose a two-fold increase was found after 2 days and a three- to four-fold increase after 16 days; normal pretreatment values were restored 16 days after cessation of etretin. This is the first demonstration in vivo that a retinoid can modulate IL1 content in a tissue. As epidermal IL1 has been found to be decreased in psoriasis, its modulation by retinoids might have therapeutic significance.
- Subjects
DRUG administration; ETRETINATE; PROSTAGLANDINS; INTERLEUKIN-1; EPIDERMIS; TRETINOIN; PSORIASIS; RETINOIDS
- Publication
British Journal of Dermatology, 1987, Vol 116, Issue 5, p615
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1987.tb05893.x