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- Title
Mononuclear cell subpopulations in the skin denned by monoclonal antibodies after HLA -- identical sibling marrow transplantation.
- Authors
Atkinson, K.; Munro, V.; Vasak, E.; Biggs, J.
- Abstract
Mononuclear cell subpopulations present in the skin of 36 recipients of HLA-identical sibling marrow transplants were defined by immunoperoxidase using a battery of monoclonal antibodies to cell surface differentiation antigens. The T4-positive (T4+) (helper-inducer T cells), T8+ (cytotoxic-suppressor T cells) and the T6+ (Langerhans cells) decreased in number early post transplant and returned towards normal numbers from day 42 onwards. There was no evidence that either the T4+ or the T8+ subset was involved in cell-to-cell contact damage in acute graft-versus-host disease (GVHD). The paucity of lymphoid cell infiltration of the epidermis in acute GVHD suggested the possibility of a soluble factor being responsible for basal layer damage. In patients with chronic GVHD there was no evidence of T4 + lymphocyte involvement, but T8+ lymphocytes were present in increased numbers, suggesting a role for the T8 + population in the skin lesions of chronic GVHD, or possibly a reflection of the pattern of T4 + and T8+ cell reconstitution in the blood post-transplant. Finally, our study provided no evidence that B1+ (B cells), Leu 7+ (natural killer cells), OKMr+ (histiocytes) or OKT10+ cells were involved in cell-to-cell contact damage in either acute or chronic GVHD.
- Subjects
BONE marrow transplantation; BONE marrow transplant complications; GRAFT versus host disease; SKIN diseases; DERMATOLOGY; HEMATOLOGY; CYTOLOGY
- Publication
British Journal of Dermatology, 1986, Vol 114, Issue 2, p145
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1986.tb02793.x