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- Title
The dilution of proprietary corticosteroid ointments--an attempt to evaluate relative clinical potencies.
- Authors
Gibson, J. R.; Darley, C.; Kirsch, J.; Saihan, E. M.; Neild, V. S.
- Abstract
Ten subjects were assessed using the vasoconstrictor assay technique in a double-blind study in order to evaluate the potencies of several diluted and undiluted proprietary corticosteroid ointments. Results showed that clobetasol propionate 0.05% (Dermovate®) ointment at a dilution of one part in ten (clobetasol propionate 0.005%) in white soft paraffin was equipotent with betamethasone valerate 0.1% (Betnovate®) ointment; and no difference in potency was demonstrated between beclomethasone dipropionate 0.025% (Propaderm®), betamethasone valerate 0.1% (Betnovate®) and clobetasone butyrate 0.05% (Eumovate®).
- Subjects
CORTICOSTEROIDS; VASOCONSTRICTORS; OINTMENTS; CARDIOVASCULAR agents; STEROID hormones; SOLID dosage forms; DILUTION
- Publication
British Journal of Dermatology, 1982, Vol 106, Issue 4, p445
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1982.tb04538.x