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- Title
ルリコナゾールの白癬菌に対するin vitro抗真菌活性 -MICおよびMFCの同時測定による既存外用抗真菌薬との比較試験-
- Authors
Maeda Jun; Nanjō Yasuko; Koga Hiroyasu; Toga Tetsuo; Makimura Kōichi; Tsuboi Ryōji
- Abstract
The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of luliconazole against Trichophyton rubrum (14 strains) and Trichophyton mentagrophytes (14 strains), which are the most common cause of tinea, were compared with those of 6 topical antifungal drugs of lanoconazole, bifonazole, efinaconazole, liranaftate, naftifine and terbinafine. Luliconazole showed the most potent antifungal activity (MIC90 =0.00098 μg/ml and MFC90 =0.0078 μg/ml) among the compounds tested against the two species. Efinaconazole and bifonazole, the drug of azole-class, showed a large MFC/MIC ratio. On the other hand, these ratios of luliconazole and lanoconazole were as small as those of liranaftate, naftifine and terbinafine which are thought to possess fungicidal mechanism. These results suggest that luliconazole possesses fungicidal activity against both species of Trichophyton. In this study, we found that luliconazole had the most potent antifungal activity among the major topical antimycotics used in Japan and the US. Luliconazole would be the best-in-class drug for dermatophytosis in clinics.
- Subjects
EFFECT of drugs on microorganisms; ANTIFUNGAL agents; TRICHOPHYTON; RINGWORM; FUNGICIDES
- Publication
Medical Mycology Journal, 2016, Vol 57, Issue 1, pJ1
- ISSN
2185-6486
- Publication type
Article