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- Title
Timing of maternal vaccination against COVID-19 for effective protection of neonates: cohort study.
- Authors
Nowakowska, Aleksandra; Seung Mi Lee; Minjee Kim; Jungmin Chun; Sehyun Kim; Byung Chul Kim; Hyun Ju In; Eunji Lee; Chanyeong Lee; Hyeondong Lee; Yuyeon Jang; Hansam Cho; Jinha Kim; Jeesun Lee; Hee-Jung Lee; Yoo-Kyoung Lee; Joong Shin Park; Young Bong Kim
- Abstract
Introduction: Although the safety and effectiveness of COVID-19 vaccination during pregnancy have been proven, there is still little data explaining neonatal outcomes of maternal pre-pregnancy vaccination. Methods: Here, we investigated the impact of vaccination and SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving 141 pregnant individuals, and defined the importance of maternal COVID-19 vaccination timing for its effectiveness. Results and discussion: Our data indicate that vertically transferred maternal hybrid immunity provides significantly better antiviral protection for a neonate than either maternal post-infection or post-vaccination immunity alone. Higher neutralization potency among mothers immunized before pregnancy and their newborns highlights the promising role of pre-pregnancy vaccination in neonatal protection. A comparison of neutralizing antibody titers calculated for each dyad suggests that infection and pre-/during-pregnancy vaccination all support transplacental transfer, providing the offspring with strong passive immunity against SARS-CoV-2. Analysis of neutralizing antibody levels in maternal sera collected during pregnancy and later during delivery shows that immunization may exert a positive effect on maternal protection.
- Subjects
PREGNANT women; COVID-19 vaccines; COHORT analysis; NEWBORN infants; MATERNALLY acquired immunity
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1359209