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- Title
Bariatric surgery for Prader‐Willi syndrome was ineffective in producing sustainable weight loss: Long term results for up to 10 years.
- Authors
Liu, Shirley Yuk‐Wah; Wong, Simon Kin‐Hung; Lam, Candice Chuen‐Hing; Ng, Enders Kwok‐Wai
- Abstract
Summary: Background: Obesity control in Prader‐Willi syndrome (PWS) is notoriously difficult. The role of bariatric surgery in PWS remains controversial as long‐term data are lacking. Objectives: To evaluate the 10‐year outcomes of bariatric surgery in PWS. Methods: This was a prospective observational study on PWS patients who received bariatric surgery and multidisciplinary follow‐up programmes for obesity control. Outcomes on weight reduction and comorbidity resolution were evaluated. Results: Between 2008 and 2013, five PWS patients (two males, mean age 19.2 ± 3.0 years) with body mass index of 47.3 ± 6.9 kg m−2 received sleeve gastrectomy (n = 2), one anastomosis gastric bypass (n = 2), and Roux‐en‐Y gastric bypass (n = 1) after failing all non‐operative weight loss programmes. The median follow‐up was 8.4 ± 2.2 years. The best mean percentage of total weight loss (%TWL) was achieved at 2 years (24.7%). %TWL dropped to 23.3% at 3 years, 11.9% at 5 years, 4.1% at 8 years, and 0% at 10 years. Each patient had at least three comorbidities preoperatively, but none of them had resolution of any one of the comorbidities at the last follow‐up. Conclusions: Bariatric surgery could not produce sustainable long‐term weight loss or comorbidity resolution in PWS. This study suggests that bariatric surgery cannot be recommended to PWS patients as a standard treatment.
- Subjects
GASTRECTOMY; HEALTH promotion; SMALL intestine; LONGITUDINAL method; BARIATRIC surgery; CHILDHOOD obesity; SCIENTIFIC observation; PRADER-Willi syndrome; TIME; WEIGHT loss; COMORBIDITY; GASTRIC bypass; MORBID obesity; BODY mass index; TREATMENT effectiveness; PREOPERATIVE period; SURGICAL anastomosis
- Publication
Pediatric Obesity, 2020, Vol 15, Issue 1, pN.PAG
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.12575