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- Title
Risk of Developing Type 2 Diabetes in Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Study.
- Authors
Mu-Hong Chen; Wen-Hsuan Lan; Ju-Wei Hsu; Kai-Lin Huang; Tung-Ping Su; Cheng-Ta Li; Wei-Chen Lin; Chia-Fen Tsai; Ying-Chiao Lee; Ying-Sheue Chen; Tai-Long Pan; Wen-Han Chang; Tzeng-Ji Chen; Ya-Mei Bai; Chen, Mu-Hong; Lan, Wen-Hsuan; Hsu, Ju-Wei; Huang, Kai-Lin; Su, Tung-Ping; Li, Cheng-Ta
- Abstract
<bold>Objective: </bold>Studies have suggested the association between autism spectrum disorder (ASD) and type 2 diabetes mellitus (DM)-related risk factors, such as obesity and dyslipidemia. However, the association between ASD and type 2 DM remains unknown.<bold>Research Design and Methods: </bold>We used the Taiwan National Health Insurance Research Database for enrolling 6,122 adolescents and young adults with ASD and 24,488 age- and sex-matched control subjects between 2002 and 2009 and monitored them until the end of 2011. Participants who developed type 2 DM during the follow-up period were identified.<bold>Results: </bold>Adolescents (hazard ratio [HR] 2.71 [95% CI 1.64-4.48]) and young adults (HR 5.31 [95% CI 2.85-9.90]) with ASD had a higher risk of developing type 2 DM than those without ASD, after adjustment for demographic data, atypical antipsychotics use, and medical comorbidities. Sensitivity analyses after excluding first year (HR 3.03 [95% CI 2.03-4.51]) and first 3-year (HR 2.62 [95% CI 1.62-4.23]) observation periods were consistent. Short-term (HR 1.97 [95% CI 1.20-3.23]) and long-term (HR 1.64 [95% CI 1.02-2.63]) use of atypical antipsychotics were associated with a higher likelihood of subsequent type 2 DM.<bold>Conclusions: </bold>Adolescents and young adults with ASD were more likely to develop type 2 DM during the follow-up. In addition, those with ASD using atypical antipsychotics exhibited a high risk. Therefore, further research is necessary to investigate the common pathophysiology of ASD and type 2 DM.
- Subjects
TAIWAN; TYPE 2 diabetes; AUTISM spectrum disorders; ANTIPSYCHOTIC agents; PATHOLOGICAL physiology; DYSLIPIDEMIA; PATIENTS; TYPE 2 diabetes complications; AGE distribution; AGE factors in disease; LONGITUDINAL method; COMORBIDITY; PROPORTIONAL hazards models
- Publication
Diabetes Care, 2016, Vol 39, Issue 5, p788
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc15-1807