We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.
- Authors
PARKINSON, O. T.; KELLY, E. J.; BEZABIH, E.; WHITTINGTON, D.; RETTIE, A. E.
- Abstract
The article discusses a study on the bioactivation of 4-Ipomeanol (IPO) fluranoterpenoid toxin by CYP4B enzyme and inhibition by HETOO16 in bovine lung. The study uses an in vitro bioactivation assay with nucleophilic amino acids N-acetyl-lysine (NAL) and N-acetyl-cysteine (NAC) to generate a stable IPO and trap a reactive ene-dial intermediate. It concludes that CYP4B1 chemical inhibitors is not an effective therapeutic method for cattle post-ingestion treatment of IPO or perilla ketone.
- Subjects
BIOTRANSFORMATION (Metabolism); BOS; LUNGS; TOXINS; CHEMICAL inhibitors; AMINO acids
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2012, Vol 35, Issue 4, p402
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2011.01339.x