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- Title
Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel.
- Authors
Behar, Adi; Baker, Kate Susan; Bassal, Ravit; Ezernitchi, Analia; Valinsky, Lea; Thomson, Nicholas R.; Cohen, Daniel
- Abstract
Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes, and little genetic variation within the O antigen: highly relevant for Shigella vaccine development.
- Subjects
MICROEVOLUTION; SHIGELLA sonnei; INFECTIOUS disease transmission; SHIGELLOSIS; NUCLEOTIDE sequencing; TETRACYCLINE; VACCINE manufacturing; DRUG resistance; THERAPEUTICS
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 7, p1335
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2407.171313