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- Title
Multidrug-resistant tuberculosis, People's Republic of China, 2007-2009.
- Authors
He GX; Wang HY; Borgdorff MW; van Soolingen D; van der Werf MJ; Liu ZM; Li XZ; Guo H; Zhao YL; Varma JK; Tostado CP; van den Hof S; He, Guang Xue; Wang, Hai Ying; Borgdorff, Martien W; van Soolingen, Dick; van der Werf, Marieke J; Liu, Zhi Min; Li, Xue Zheng; Guo, Hui
- Abstract
We conducted a case-control study to investigate risk factors for multidrug-resistant tuberculosis (MDR TB) in the People's Republic of China. Genotyping analysis was used to estimate the percentage of cases from recent transmission among 100 MDR TB case-patients hospitalized during April 2007-July 2009. Molecular subtyping of isolates showed that 41% of MDR TB strains clustered. Beijing genotype was found in 94% of the MDR TB isolates and 79% of the pan-susceptible isolates. In multivariate analysis, MDR TB was independently associated with Beijing genotype, retreatment for TB, symptoms lasting >3 months before first evaluation at the hospital, lack of health insurance, and being a farmer (vs. being a student). MDR TB was associated with Beijing genotype and lower socioeconomic status. A large percentage of MDR TB cases seemed to result from recent transmission. Early detection, effective treatment, and infection control measures for MDR TB are needed to reduce transmission.
- Publication
Emerging Infectious Diseases, 2011, Vol 17, Issue 10, p1831
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1710.110546