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- Title
HIV-1 Genetic Diversity in Antenatal Cohort, Canada.
- Authors
Akouamba, Bertine S.; Viel, Janique; Charest, Hugues; Merindol, Natacha; Samson, Johanne; Lapointe, Normand; Brenner, Bluma G.; Lalonde, Richard; Harrigan, P. Richard; Boucher, Marc; Soudeyns, Hugo
- Abstract
We studied HIV genetic diversity in a cohort of 127 pregnant, HIV-infected women who received prenatal care at Sainte-Justine Hospital in Montreal, Canada, between 1999 and 2003. Clade assignments were derived by phylogenetic analysis of amplified pol sequences. Genotyping was successful in 103 of 127 women, 59 (57.3%) of whom were infected with clade B HIV-1, and 44 (42.7%) with non-clade B viruses, including subtypes A, C, D, P, G, and H. Four sequences remained unassigned. Forty-three of 44 women infected with non-clade B viruses were newcomers from sub-Saharan Africa, and subtype identity was consistent with those circulating in their countries of origin. These results highlight the epidemiologic importance of non-B HIV-1 in antenatal populations in a large North American urban center, underscore the influence of population movements on clade intermixing, and identify a group of patients who could be targeted for surveillance and drug therapy follow up.
- Subjects
CANADA; HIV; PRENATAL diagnosis; HIV-positive women; PRENATAL care; GENOTYPE-environment interaction
- Publication
Emerging Infectious Diseases, 2005, Vol 11, Issue 8, p1230
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1108.040877