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- Title
Oral sildenafil citrate lacks genotoxicity and cytotoxicity in a primate model: Callithrix jacchus.
- Authors
Lemus-Varela, M. L.; Sola, A.; Gómez-Meda, B. C.; Zamora-Perez, A. L.; Ramos-Ibarra, M. L.; Batista-González, C. M.; Zúñiga-González, G. M.
- Abstract
Objective:To determine sildenafil citrate (SC) genotoxicity and cytotoxicity in the Callithrix jacchus.Study design:Fifteen organisms were assigned to one of three groups as follows: experimental (25 mg/kg of SC); negative control (glucose solution 5%); and positive control (3 mg/kg of cytocine arabinoside). Systemic hemodynamic changes were monitored in each animal before and after each treatment. A drop of blood was obtained before and after the treatment at 24–120 h. Smears were made and the frequency of micronucleated erythrocytes (MNE), micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes (PCE) was counted.Results:No significant differences in MNE, MNPCE and PCE were found in the group that received sildenafil and negative control. A significant increase in genotoxicity and cytotoxicity was observed in the positive control group. No changes were observed in systemic hemodynamic changes.Conclusion:The macro-dose of SC lacks genotoxic, cytotoxic or systemic hemodynamic changes effects in this species.Journal of Perinatology (2006) 26, 423–427. doi:10.1038/sj.jp.7211518; published online 4 May 2006
- Subjects
CALLITHRIX jacchus; SILDENAFIL; OBSTETRICS; CALLITHRIX; CITRATES
- Publication
Journal of Perinatology, 2006, Vol 26, Issue 7, p423
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/sj.jp.7211518