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- Title
Eucommiae Cortex Inhibits TNF-α and IL-6 Through the Suppression of Caspase-1 in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages.
- Authors
Kim, Min-Cheol; Kim, Dae-Seung; Kim, Su-Jin; Park, Jinbong; Kim, Hye-Lin; Kim, Seon-Young; Ahn, Kwang Seok; Jang, Hyeung-Jin; Lee, Seok-Geun; Lee, Kang-Min; Hong, Seung-Heon; Um, Jae-Young
- Abstract
Eucommiae cortex (EC) is used in various traditional Korean medicines in the form of tonics, analgesics, and sedatives. However, the underlying mechanism of its anti-inflammatory effect remains unclear. This study attempts to determine the effects of EC on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. The findings of the study show that EC inhibits the LPS-induced production of tumor necrosis factor-alpha and interleukin-6. Exposure to EC also reduces an inflammation-induced increase in the levels of cyclooxigenase-2 and the production of prostaglandin E2 and nitric oxide in mouse peritoneal macrophages. Furthermore, EC suppresses the activation of nuclear factor-kappa B and caspase-1. These results provide novel insights into the pharmacological action of EC and indicate that EC has a potential in the treatment of inflammatory diseases.
- Publication
American Journal of Chinese Medicine, 2012, Vol 40, Issue 1, p135
- ISSN
0192-415X
- Publication type
Journal Article