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- Title
Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis.
- Authors
Datta, Gourab; Violante, Ines R.; Scott, Gregory; Zimmerman, Karl; Santos-Ribeiro, Andre; Rabiner, Eugenii A.; Gunn, Roger N.; Malik, Omar; Ciccarelli, Olga; Nicholas, Richard; Matthews, Paul M.
- Abstract
Background: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. Objective: To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. Methods: A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability was assessed by Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC). Results: [11C]PBR28 uptake and [myo-inositol] were not associated. When the whole cohort was stratified by higher [11C]PBR28 inflammatory burden, [myo-inositol] was positively correlated to [11C]PBR28 uptake (Spearman's ρ = 0.685, p = 0.014). Moderate correlations were found between [11C]PBR28 uptake and both MRS creatine normalised N-acetyl aspartate (NAA) concentration and grey matter volume. MSFC was correlated with grey matter volume (ρ = 0.535, p = 0.009). There were no associations between other imaging or clinical measures. Conclusion: MRS [myo-inositol] and PET [11C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [11C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.
- Subjects
MULTIPLE sclerosis; POSITRON emission tomography; MAGNETIC resonance imaging; NEUROGLIA; MICROGLIA; ASTROCYTES; TRANSLOCATOR proteins; INFLAMMATION
- Publication
Multiple Sclerosis Journal, 2017, Vol 23, Issue 11, p1469
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458516681504