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- Title
Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study.
- Authors
Mancuso, R; Franciotta, D; Rovaris, M; Caputo, D; Sala, A; Hernis, A; Agostini, S; Calvo, MG; Clerici, M
- Abstract
Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.
- Subjects
NATALIZUMAB; MONOCLONAL antibodies; IMMUNOGLOBULIN G; OLIGOCLONAL bands; CEREBROSPINAL fluid; MULTIPLE sclerosis; PHYSIOLOGY; PATIENTS; THERAPEUTICS
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 14, p1900
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458514538111