We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.
- Authors
Hegen, H; Millonig, A; Bertolotto, A; Comabella, M; Giovanonni, G; Guger, M; Hoelzl, M; Khalil, M; Killestein, J; Lindberg, R; Malucchi, S; Mehling, M; Montalban, X; Polman, CH; Rudzki, D; Schautzer, F; Sellebjerg, F; Sørensen, PS; Deisenhammer, F
- Abstract
The article presents a study of the potential of early binding antibody (BAb) titers or different interferon-beta (IFN-b) biomarkers to predict neutralizing antibodies (NAb). The study included patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS) that receive de novo IFN-b treatment. Results showed that BAb titers reliably predict Nabs, with CXCL-10 as a potential sensitive biomarker for IFN-b response and abrogation by anti-IFN-b antibodies.
- Subjects
IMMUNOGLOBULINS; INTERFERONS; MULTIPLE sclerosis; TITERS; DRUG resistance; BIOMARKERS; PATIENTS
- Publication
Multiple Sclerosis Journal, 2014, Vol 20, Issue 5, p577
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458513503597