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- Title
Evidence for a colorectal cancer susceptibility locus on chromosome 3q21–q24 from a high-density SNP genome-wide linkage scan.
- Authors
Kemp, Zoe; Carvajal-Carmona, Luis; Spain, Sarah; Barclay, Ella; Gorman, Margaret; Martin, Lynn; Jaeger, Emma; Brooks, Neil; Bishop, D. Timothy; Thomas, Huw; Tomlinson, Ian; Papaemmanuil, Elli; Webb, Emily; Sellick, Gabrielle S; Wood, Wendy; Evans, Gareth; Lucassen, Anneke; Maher, Eamonn R; Houlston, Richard S
- Abstract
To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal neoplasia in which involvement of known loci had been excluded, using a high-density single nucleotide polymorphism (SNP) array containing 10 204 markers. Multipoint linkage analyses were undertaken using both non-parametric (model-free) and parametric (model-based) methods. After the removal of SNPs in strong linkage disequilibrium, we obtained a maximum non-parametric linkage statistic of 3.40 (P=0.0003) at chromosomal region 3q21–q24. The same genomic position also yielded the highest multipoint heterogeneity LOD (HLOD) score under a dominant model (HLOD=3.10, genome-wide P=0.038) with 62% of families linked to the locus. We provide evidence for a novel CRC susceptibility gene. Further studies are needed to confirm this localization and to evaluate the contribution of this locus to disease incidence.
- Publication
Human Molecular Genetics, 2006, Vol 15, Issue 19, p2903
- ISSN
0964-6906
- Publication type
Article
- DOI
10.1093/hmg/ddl231