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- Title
Hepato-protective Activity of Methanolic Extract of Persea americana Leaves in Albino Rats.
- Authors
Sapna, Malviya; Ankur, Joshi; Narendra, Vyas; Ashok, Koshta; Anil, Kharia
- Abstract
The present study aimed to determine the hepatoprotective activity of a methanolic extract of Persea americana leaves using CCl4 induced hepatotoxicity. Ten groups of rats (n=6) were given orally administration of 10% dimethyl sulfoxide (negative control), 200 mg/kg silymarin (positive control), or Persea americana leaves (50, 250, or 500 mg/kg) daily for seven days followed by induction of hepatotoxicity using carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, P. americana leaves extracts exhibited a significant (p < 0.05) hepatoprotective activity against inducer, as indicated by an improvement in the liver function test. These findings were correlated with the histopathological studies. In conclusion, P. americana leaves possessed hepatoprotective activity, which could be due to phytochemical constituents and antioxidant activity.
- Subjects
AVOCADO; HEPATOTOXICOLOGY; METHANOL; PLANT extracts; SILYMARIN; LABORATORY rats; PREVENTION; THERAPEUTICS
- Publication
International Journal of Pharmacy & Life Sciences, 2018, Vol 9, Issue 2, p79
- ISSN
0976-7126
- Publication type
Article