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- Title
Copper-Catalyzed Isomerization and Cyclization of E/ Z- o-Haloaryl N-Sulfonylhydrazones: Convenient Access to 1 H-Indazoles.
- Authors
Zhu, Xue‐Qing; Mao, Shuai; Guo, Dong‐Dong; Li, Bin; Guo, Shi‐Huan; Gao, Ya‐Ru; Wang, Yong‐Qiang
- Abstract
The isomerization of the C=N double bond in hydrazones has drawn considerable attention because of its potential for application in a broad range of chemical transformations. Generally, this isomerization can be realized either photochemically or thermally. A new isomerization approach is presented, namely a copper-catalyzed C=N double bond isomerization of hydrazones, which is followed by an efficient intramolecular C−N coupling reaction, providing an unprecedented catalytic approach for the synthesis of 1 H-indazoles from readily accessible Z/ E mixture of o-haloaryl N-sulfonylhydrazones.
- Subjects
COPPER catalysts; HYDRAZONES; CATALYTIC isomerization; RING formation (Chemistry); HETEROCYCLIC compounds; INDAZOLES
- Publication
ChemCatChem, 2017, Vol 9, Issue 6, p1084
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201601243