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- Title
A replication-defective human cytomegalovirus vaccine for prevention of congenital infection.
- Authors
Dai Wang; Freed, Daniel C.; Xi He; Fengsheng Li; Aimin Tang; Cox, Kara S.; Dubey, Sheri A.; Cole, Suzanne; Medi, Muneeswara Babu; Yaping Liu; Jingyuan Xu; Zhi-Qiang Zhang; Finnefrock, Adam C.; Song, Liping; Espeseth, Amy S.; Shiver, John W.; Casimiro, Danilo R.; Tong-Ming Fu
- Abstract
The article discusses a study on the use of a replication-defective human cytomegalovirus vaccine to prevent congenital infection. The study examined a vaccine candidate with genetic modifications to improve its immunogenicity and attenuation. It used a synthetic compound named Shield-1 to regulate viral replication. The results revealed that the vaccine induced neutralizing antibodies to multiple viral antigens.
- Subjects
CYTOMEGALOVIRUS diseases; CONGENITAL disorders; CYTOMEGALOVIRUSES; VIRAL replication; IMMUNOGLOBULINS; VIRAL antigens; VACCINATION
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 362, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf9387