We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
P53 and microRNAs in chronic lymphocytic leukemia.
- Authors
Bloehdorn, Johannes; Langer, Christian; Döhner, Hartmut; Zenz, Thorsten; Stilgenbauer, Stephan
- Abstract
There has been considerable progress in characterising chronic lymphocytic leukemia with respect to the underlying biology and the corresponding clinical presentation. Most patients with CLL live for years without the need for therapy. This does not hold true for patients that exhibit inactivation of the tumour suppressor p53 or, possibly, its pathway members. Deletions of chromosome 17p and mutations of TP53 are the main characteristic of aggressive and refractory disease. In this review we will outline the current understanding of mechanisms known to contribute to dysfunctional p53 and its connection to microRNAs.
- Subjects
CHRONIC lymphocytic leukemia; DISEASE progression; TUMOR suppressor genes; CHROMOSOMES; MICRORNA; GENETIC research
- Publication
Journal of Nucleic Acids Investigation, 2011, Vol 2, Issue 1-3, p43
- ISSN
2036-7996
- Publication type
Article
- DOI
10.4081/jnai.2011.2414