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- Title
Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction.
- Authors
Edelmann, Frank; Wachter, Rolf; Schmidt, Albrecht G.; Kraigher-Krainer, Elisabeth; Colantonio, Caterina; Kamke, Wolfram; Duvinage, André; Stahrenberg, Raoul; Durstewitz, Kathleen; Löfller, Markus; Düngen, Hans-Dirk; Tschöpe, Carsten; Herrmann-Lingen, Christoph; Halle, Martin; Hasenfuss, Gerd; Gelbrich, Götz; Pieske, Burkert
- Abstract
The article focuses on a randomized controlled trial to assess the efficacy and safety of long-term aldosterone receptor blockade in heart failure with preserved ejection fraction. The objective of trials was to determine the role of spironolactone to improve diastolic function and maximal exercise capacity in patients with heart failure. It mentions that the trial was conducted between March 2007 and April 2012 at 10 sites in Germany and Austria that included 422 ambulatory patients. Patients were randomly assigned to receive 25 mg of spironolactone or placebo once daily. The diastolic function on echocardiography and maximal exercise capacity were measured, showing improvement in left ventricular diastolic function but no effect on maximal exercise capacity.
- Subjects
GERMANY; AUSTRIA; RANDOMIZED controlled trials; SPIRONOLACTONE; HEART failure treatment; DIASTOLE (Cardiac cycle); MINERALOCORTICOID receptors; STRESS echocardiography; CARDIAC patients; PLACEBOS; EXERCISE tests; ECHOCARDIOGRAPHY; THERAPEUTICS
- Publication
JAMA: Journal of the American Medical Association, 2013, Vol 309, Issue 8, p781
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2013.905