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- Title
Correlation of cortisol in 1-cm hair segment with salivary cortisol in human: hair cortisol as an endogenous biomarker.
- Authors
Xie, Qiaozhen; Gao, Wei; Li, Jifeng; Qiao, Ting; Jin, Jing; Deng, Huihua; Lu, Zuhong
- Abstract
Background: Cortisol level in human hair would be an endogenous biomarker for the retrospective assessment of long-term central hypothalamo-pituitary-adrenal activity. However, no direct evidence supports that blood-related diffusion is a biologically endogenous source of hair cortisol in humans. The present study aims to validate the direct correlation between cortisol in 1-cm hair segments and salivary cortisol in healthy humans. Methods: We collected three saliva samples from the same participant at Time 1, Time 2 (1 week later) and Time 3 (2 weeks later), and hair 4 weeks later. Cortisol levels in 1-cm hair segments and saliva were determined with high performance liquid chromatography tandem mass spectrometry. Results: Salivary cortisol at Time 1 was significantly associated with that at Time 2 (r=0.514, p=0.003), but not with that at Time 3 (r=0.187, p=0.305); and the one at Time 2 was significantly associated with that at Time 3 (r=0.380, p=0.032). Hair cortisol was significantly correlated with salivary cortisol at Time 2 (r=0.389, p<0.05) and average salivary cortisol (r=0.383, p<0.05) from three sampling. Conclusions: Our results confirmed that blood-related diffusion mechanism is a biologically endogenous source of hair cortisol.
- Subjects
STATISTICAL correlation; HAIR analysis; BIOMARKERS; HIGH performance liquid chromatography; TANDEM mass spectrometry; BLOOD sampling; HYDROCORTISONE regulation; DIFFUSION
- Publication
Clinical Chemistry & Laboratory Medicine, 2011, Vol 49, Issue 12, p2013
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/CCLM.2011.706