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- Title
The Relationship between Selection, Network Connectivity, and Regulatory Variation within a Population of Capsella grandiflora.
- Authors
Josephs, Emily B.; Wright, Stephen I.; Stinchcombe, John R.; Schoen, Daniel J.
- Abstract
Interactions between genes can have important consequences for how selection shapes sequence variation at these genes. Specifically, genes that have pleiotropic effects by affecting the expression level of many other genesmay be under stronger selective constraint. We used coexpression networks to measure connectivity between genes and investigated the relationship between gene connectivity and selection in a natural population of the plant Capsella grandiflora. We observed that network connectivity was negatively correlated with genetic divergence due to stronger negative selection on highly-connected genes even when controlling for variation in gene expression level. However, the presence of local regulatory variation for a gene's expression level was also associated with reduced negative selection and lower gene connectivity. While it is difficult to disentangle the causal relationships between these factors, our results show that both connectivity and local regulatory variation are important factors for explaining variation in selection between genes.
- Subjects
CAPSELLA; GENE expression; GENE regulatory networks; GENETIC regulation; PLANT genetics
- Publication
Genome Biology & Evolution, 2017, Vol 9, Issue 4, p1099
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evx068