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- Title
Foot Muscle Energy Reserves in Diabetic Patients Without and With Clinical Peripheral Neuropathy.
- Authors
Dinh, Thanh; Doupis, John; Lyons, Thomas E.; Kuchibhotla, Sarada; Julliard, Walker; Gnardellis, Charalambos; Rosenblum, Barry I.; Wang, Xiaoen; Giurini, John M.; Greenman, Robert L.; Veves, Aristidis
- Abstract
OBJECTIVE-- To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. RESEARCH DESIGN AND METHODS-- We measured the phosphocreatinine (PCr)/ inorganic phosphate (Pi) ratio, total [sup 31]p concentration, and the lipid/water ratio in the muscles in the metatarsal head region using MRI spectroscopy in healthy control subjects and nonneuropathic and neuropathic diabetic patients. RESULTS -- The PCr/Pi ratio was higher in the control subjects (3.23 ± 0.43) followed by the non-neuropathic group (2.61 ± 0.36), whereas it was lowest in the neuropathic group (0.60 ± 1.02) (P < 0.0001). There were no differences in total [sup 31]p concentration and lipid/water ratio between the control and non-neuropathic groups, but both measurements were different in the neuropathic group (P < 0.0001). CONCLUSIONS -- Resting foot muscle energy reserves are affected before the development of peripheral diabetic neuropathy and are associated with the endothelial dysfunction and inflammation.
- Subjects
MUSCLES; FOOT; PEOPLE with diabetes; DIABETIC neuropathies; PHOSPHOCREATINE; PHOSPHORUS in the body; ENDOTHELIUM diseases
- Publication
Diabetes Care, 2009, Vol 32, Issue 8, p1521
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-0536